Development of the lymphatic vascular system: a mystery unravels.
Identifieur interne : 008824 ( Main/Exploration ); précédent : 008823; suivant : 008825Development of the lymphatic vascular system: a mystery unravels.
Auteurs : Young-Kwon Hong [États-Unis] ; Jay W. Shin ; Michael DetmarSource :
- Developmental dynamics : an official publication of the American Association of Anatomists [ 1058-8388 ] ; 2004.
Descripteurs français
- KwdFr :
- Animaux, Développement embryonnaire, Facteur de croissance endothéliale vasculaire de type A (génétique), Facteur de croissance endothéliale vasculaire de type A (métabolisme), Facteurs de croissance endothéliale (génétique), Homéostasie, Humains, Lymphangiogenèse (génétique), Lymphoedème (génétique), Marqueurs biologiques, Modèles biologiques, Peau (métabolisme), Phylogénie, Récepteurs aux facteurs de croissance endothéliale vasculaire (génétique), Récepteurs aux facteurs de croissance endothéliale vasculaire (métabolisme), Système lymphatique (embryologie), Système lymphatique (métabolisme), Vaisseaux lymphatiques (embryologie), Vaisseaux lymphatiques (métabolisme).
- MESH :
- embryologie : Système lymphatique, Vaisseaux lymphatiques.
- génétique : Facteur de croissance endothéliale vasculaire de type A, Facteurs de croissance endothéliale, Lymphangiogenèse, Lymphoedème, Récepteurs aux facteurs de croissance endothéliale vasculaire.
- métabolisme : Facteur de croissance endothéliale vasculaire de type A, Peau, Récepteurs aux facteurs de croissance endothéliale vasculaire, Système lymphatique, Vaisseaux lymphatiques.
- Animaux, Développement embryonnaire, Homéostasie, Humains, Marqueurs biologiques, Modèles biologiques, Phylogénie.
English descriptors
- KwdEn :
- Animals, Biomarkers, Embryonic Development, Endothelial Growth Factors (genetics), Homeostasis, Humans, Lymphangiogenesis (genetics), Lymphatic System (embryology), Lymphatic System (metabolism), Lymphatic Vessels (embryology), Lymphatic Vessels (metabolism), Lymphedema (genetics), Models, Biological, Phylogeny, Receptors, Vascular Endothelial Growth Factor (genetics), Receptors, Vascular Endothelial Growth Factor (metabolism), Skin (metabolism), Vascular Endothelial Growth Factor A (genetics), Vascular Endothelial Growth Factor A (metabolism).
- MESH :
- chemical , genetics : Endothelial Growth Factors, Receptors, Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor A.
- chemical , metabolism : Receptors, Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor A.
- chemical : Biomarkers.
- embryology : Lymphatic System, Lymphatic Vessels.
- genetics : Lymphangiogenesis, Lymphedema.
- metabolism : Lymphatic System, Lymphatic Vessels, Skin.
- Animals, Embryonic Development, Homeostasis, Humans, Models, Biological, Phylogeny.
Abstract
The blood vascular and the lymphatic system play complementary roles in tissue perfusion and fluid reabsorption. Despite its critical role in mediating tissue fluid homeostasis, intestinal lipid absorption, and the immune response, the lymphatic system has not received as much attention as the blood vascular system, largely due to a lack of lymphatic-specific markers and to the dearth of knowledge about the molecular regulation of lymphatic development and function. A series of recent landmark studies now significantly has advanced our understanding of the lymphatic system. Based upon the discovery and characterization of lymphatic-specific growth factors, receptors, and transcriptional regulators, the mystery of lymphatic vascular system development begins to be unraveled. The successful isolation and cultivation of blood vascular and lymphatic endothelial cells has enabled comparative molecular and cellular analyses of these two genetically and developmentally closely related cell lineages. Moreover, studies of several genetic mouse models have set the framework for a new molecular model of embryonic lymphatic vascular development and have identified molecular pathways whose mutational inactivation leads to human diseases associated with lymphedema. Although these rapid advances already have led to development of the first lymphatic-targeted molecular therapies, there still remain many unanswered questions regarding almost every aspect of lymphatic vascular biology, making the lymphatic system a highly exciting and rewarding field of study.
DOI: 10.1002/dvdy.20179
PubMed: 15376314
Affiliations:
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Despite its critical role in mediating tissue fluid homeostasis, intestinal lipid absorption, and the immune response, the lymphatic system has not received as much attention as the blood vascular system, largely due to a lack of lymphatic-specific markers and to the dearth of knowledge about the molecular regulation of lymphatic development and function. A series of recent landmark studies now significantly has advanced our understanding of the lymphatic system. Based upon the discovery and characterization of lymphatic-specific growth factors, receptors, and transcriptional regulators, the mystery of lymphatic vascular system development begins to be unraveled. The successful isolation and cultivation of blood vascular and lymphatic endothelial cells has enabled comparative molecular and cellular analyses of these two genetically and developmentally closely related cell lineages. Moreover, studies of several genetic mouse models have set the framework for a new molecular model of embryonic lymphatic vascular development and have identified molecular pathways whose mutational inactivation leads to human diseases associated with lymphedema. Although these rapid advances already have led to development of the first lymphatic-targeted molecular therapies, there still remain many unanswered questions regarding almost every aspect of lymphatic vascular biology, making the lymphatic system a highly exciting and rewarding field of study.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><noCountry><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name><name sortKey="Shin, Jay W" sort="Shin, Jay W" uniqKey="Shin J" first="Jay W" last="Shin">Jay W. Shin</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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